Sustained CD8 + T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans
Open Access
- 15 September 2005
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 79 (18) , 12117-12121
- https://doi.org/10.1128/jvi.79.18.12117-12121.2005
Abstract
Murine models have suggested that CD8 + T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8 + T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8 + T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8 + T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.Keywords
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