Reproduction, metabolism and growth are not wholly independent activities of the body. Throughout life they exert a varying influence on one another.1The relation is not always apparent; yet conception, the supreme moment of sexual activity, is the most potent of the stimuli of growth. It initiates an orderly extension and division of the mass which are not ended even at maturity, for in the phenomenon of repair they continue, with diminishing force,2throughout life. The relation between the generative and vegetative functions is not direct. On the strongest evidence, the mediacy of endocrine glands is assumed. At puberty, entrance of a sex hormone secretion into the body economy is accompanied by rapid growth, both general and sex specific, and by changes in the configuration of the body.3However, according to Nicola Pende,4pure, dominant, constitutional insufficiency of the sex glands is seldom found. More frequently