DOXEPIN OR DIAZEPAM FOR ANXIOUS AND ANXIOUS-DEPRESSED OUTPATIENTS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (2) , 135-139
Abstract
A 6 wk double-blind comparison of doxepin and diazepam in the treatment of 61 anxious outpatients showed few drug differences. Diazepam treated patients improved significantly more early in the trial, according to a few measures. They also had significantly fewer complaints of drowsiness. By 6 wk, the medicines appeared roughly equal in efficacy. Practically no support was found for the position that doxepin may be more beneficial for anxious-depressive syndromes. In all patients, and also within the anxious-depressive subgroup, there were small mean differences on many criteria favoring doxepin at 6 wk, but none reached significance. The doxepin group gained significantly more weight. Possible biasing influences were present requiring that the results be interpreted with particular caution.

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