Adverse skin reaction from vitamin KI

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Abstract
Two patients with erythematous, tender, indurated plaques at the site of i.m. injections of vitamin KI are described. In 1 of these, the condition was reproduced by the injection of a test dose. In both cases, there was associated liver disease. The red, indurated plaques cleared in 4-14 days. There are 2 previous reports in the literature of similar lesions, although some of the patients showed sclerodermatous changes at the same site within 2 yr of the injections. These unusual reactions were only seen in patients with liver disease and when a variety of drugs were administered. It may be that these factors are important in the initiation of the cutaneous response.

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