Theophylline in Asthma

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Abstract
Theophylline has been a popular medication for asthma for over 50 years. However, the introduction of newer pharmacologic agents, concern about the toxicity of theophylline, and recommendations in widely disseminated guidelines have recently contributed to its decreased use. In this review we reassess the role of theophylline in the pharmacotherapy of asthma and specifically address three pivotal questions: What are the data justifying its continued use? What are its risks? What is its role in the treatment of patients with asthma?HistoryAlthough first used as intravenous therapy for acute asthma1 and then as an oral medication in fixed doses . . .