Elevation of Erythrocyte Countertransport Rates in Alzheimer's Dementia
- 27 October 1983
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 309 (17) , 1061-1062
- https://doi.org/10.1056/nejm198310273091717
Abstract
To the Editor: The dementia of Alzheimer's disease incapacitates many elderly people in the United States. The diagnosis can usually be verified on autopsy by characteristic neuropathologic changes. However, this and other conditions with similar behavioral manifestations are hard to distinguish in the living patient, because valid diagnostic laboratory markers have not yet been established.1 We report preliminary evidence, based on an open study of a small sample, that sodium–lithium countertransport is elevated in erythrocytes of patients with Alzheimer's disease. Our sample consisted of elderly white women: four patients with a preliminary clinical diagnosis of Alzheimer's dementia on the basis . . .Keywords
This publication has 9 references indexed in Scilit:
- THE DEMENTIA SYNDROMEThe Lancet, 1982
- Philothermal response of polymorphonuclear leukocytes in dementia of the Alzheimer typeNeurobiology of Aging, 1982
- Increased Red-Cell Sodium-Lithium Countertransport in Normotensive Sons of Hypertensive ParentsNew England Journal of Medicine, 1982
- Lithium-induced changes in sodium-lithium countertransportBiochemical Pharmacology, 1981
- Lithium, membranes, and manic-depressive illnessThe Journal of Membrane Biology, 1980
- Increased Sodium-Lithium Countertransport in Red Cells of Patients with Essential HypertensionNew England Journal of Medicine, 1980
- Lithium fluxes in human erythrocytesAmerican Journal of Physiology-Cell Physiology, 1979
- Genetic Determinant of Lithium Ion DistributionArchives of General Psychiatry, 1975