INFLUENCE OF HAEMODILUTION ON THE POTENCY OFNEUROMUSCULAR BLOCKING DRUGS

Open Access

1 March 1981

journal article
research article
Published by Elsevier in British Journal of Anaesthesia

Vol. 53 (3) , 263-265
https://doi.org/10.1093/bja/53.3.263

Abstract

The potencies of suxamethonium, pancuronium, and tubocurarine were increased, as shown by a parallel shift to the left of cumulative dose-response curves, following normovolaemic haemodilution before operation. This is attributed to an increase in cardiac output, to a decrease in protein binding and, in the case of suxamethonium, to a decrease in cholincsterasc activity.

Keywords

HEMODILUTION
NEUROMUSCULAR BLOCKING AGENTS
SUCCINYLCHOLINE
TUBOCURARINE
SHIFT TO THE LEFT
PANCURONIUM
PROTEIN BINDING
CARDIAC OUTPUT

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