Low-Dose Heparin in Proximal Femoral Fractures:Failure to Prevent Deep-Vein Thrombosis

1 January 1981

journal article
research article
Published by Medical Journals Sweden AB in Acta Orthopaedica

Vol. 52 (1) , 77-80
https://doi.org/10.3109/17453678108991763

Abstract

The effect of heparin, 5000 units every 8 hours, on deep venous thrombosis in patients with proximal femoral fractures was investigated in a controlled, double blind, randomised study. Heparin or placebo was administered as soon as possible after the fracture, and before 6 hours had passed, and was continued for 14 days. The diagnosis of deep venous thrombosis was made using daily I₁₂₅ fibrinogen scans. A total of 130 patients entered the trial and the results were registered on a sequential diagram. This showed that the 0-hypothesis could not be rejected, and that consequently no difference in the frequency of deep-vein thrombosis was detected.

Keywords

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