Molecular characterization of acute myeloid leukemia

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Abstract
Cute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized by the accumulation of acquired somatic genetic alterations in hematopoietic progenitor cells that alter normal mechanisms of self-renewal, proliferation and differentiation. 1 Non-random clonal chromosome aber- rations (i.e., balanced translocations, inversions, dele- tions, monosomies, and trisomies) are detectable in the leukemic blasts of approximately 55% of adults with AML. These chromosome changes have contributed to the classification of the disease and in the past they have been recognized as the most important prognos- tic factor for achievement of complete remission, risk of relapse, and overall survival.
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