INTERACTION OF PLASMA-MEMBRANES WITH INFLUENZA-VIRUS .6. POSSIBLE ROLE OF ADENYLATE-CYCLASE SYSTEM

  • 1 January 1976
    • journal article
    • research article
    • Vol. 20  (4) , 283-290
Abstract
The amounts of released soluble (s) antigen of influenza A/WSN virus were increased when the virus was allowed to interact with isolated [chicken embryo cell] plasma membranes in a medium containing substances enhancing the level of cyclic[c'']AMP or activating the enzyme adenylate cyclase. By contrast, less s-antigen was released upon addition to the incubation medium of fetal calf serum or calf serum proteins which activate c''AMP phosphodiesterase and thus decrease the level of c''AMP. Changes in the amount of released s-antigen were parallelled by changes in the activities of membrane Ca-ATPase and creatine phosphokinase.

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