EFFECT OF TERBUTALINE ON CARDIOVASCULAR STATE AND UTERINE BLOOD-FLOW IN PREGNANT EWES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 50  (5) , 603-606
Abstract
Cardiovascular and uterine hemodynamic effects of terbutaline, a .beta.-adrenergic receptor stimulant and labor inhibiting agent, were evaluated in the chronically instrumented near-term pregnant ewe. Administration of terbutaline in the dose range required for labor inhibition in this species resulted in a mild maternal tachycardia and increase in pulse pressure without significant changes in uterine blood flow, uterine vascular resistance or systolic, diastolic or mean blood pressures. With infusion rates of terbutaline in excess of those required for labor inhibition, significant increases in maternal heart rate, pulse pressure and systolic blood pressure were observed. Diastolic blood pressure decreased significantly during higher infusion rates; however, uterine blood flow was unaffected. The minimal cardiovascular and uterine hemodynamic effects noted with administration of tertutaline in the dose range necessary for labor inhibition indicate that this agent may possess advantages over several others currently in use for treatment of premature labor.

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