Cytotoxicity of 2-Chlorodeoxadenosine (Cladribine, 2-cdA) in Combination with other Chemotherapy Drugs Against two Lymphoma Cell Lines
- 1 January 1999
- journal article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 33 (1-2) , 141-145
- https://doi.org/10.3109/10428199909093735
Abstract
Cladribine is a purine analog with impressive activity in patients with low-grade lymphoproliferative disorders. We studied the combination of cladribine with other antineoplastic drugs against two human-derived B-cell lymphoma cell lines in vitro. Cladribine was combined with cisplatin, daunorubicin, chlorambucil, paclitaxel or etoposide. Under the experimental conditions studied, only the combination of cladribine and cisplatin showed significantly increased cytotoxicity compared to the effect of either drug alone.Keywords
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