UTEROTROPHIC ACTIVITY OF VARIOUS PHENOLIC STEROIDS

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Abstract
The uterotrophic activity of certain steroids including 3- and/or 17-deoxy derivatives of estrone and 17[beta]-estradiol and selected alkyl derivatives was determined in a 3-day immature mouse test. The enhancement of oral activity but not subcutaneous activity by the introduction of a 17[alpha]-ethynyl group in place of a 17[alpha]-hydrogen was confirmed and extended. Other alkyl substituents reduced uterotrophic activity. Significant uterotrophic activity was associated with certain 3- and/or 17-deoxy steroids. Estra-l,3,5(10)-trien-3-ol was 11% as active as estrone by the subcutaneous route whereas 17[alpha]-estradiol was only 3.2% as active.