TRANSPLANTABLE THYROID TUMOUR IN RATS: IODOAMINO ACID DISTRIBUTION IN SUCCESSIVE TUMOUR GENERATIONS

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Abstract
All 1st generation thyroid tumors produced in rats by 3 .mu.Ci 131I followed by LID [low I diet] were uniformly functional, containing MIT [monoiodotyrosine], DIT [diiodotyrosine], T4 [thyroxine], T3 [triiodothyronine], and in some cases, T''3 [3,3'',5''-triiodothyronine]. All 4th generation tumors were nonfunctional as tested. Second and 3rd generation tumors were biochemically unpredictable, some containing all IAA [iodoamino acids], including T''3, and others only MIT, I- and a trace of DIT. The degree of dedifferentiation and autonomy did not necessarily correlate with loss of function. The results could be explained by postulating nodules with differing biochemical properties within individual tumors.