The Significance of the ‘Protein Error’ of Indicators in the Diagnosis of Bence-Jones Proteinuria

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Abstract
A comparison is made between the relative abilities of 4 frequently used laboratory methods to detect the presence of "abnormal" globulins in the urines of 19 patients with multiple myeloma or macroglobulinaemia. Discrepancies between the abilities of albumin, gamma globulin and 12 urinary M- components to displace the transformation range of an indicator strip test for proteinuria are noted, and the theoretical significance discussed. The combined findings of a negative or trace positive colorimetric strip test and a strongly or moderately positive Heller''s test, Purdy''s heat test, or sulfosalicylic acid test are shown to strongly favor the presence of gamma-related proteins in the urine.