Molecular and catalytic properties of a peroxiredoxin–glutaredoxin hybrid from Neisseria meningitidis
Open Access
- 15 October 2003
- journal article
- Published by Wiley in FEBS Letters
- Vol. 554 (1-2) , 149-153
- https://doi.org/10.1016/s0014-5793(03)01156-6
Abstract
A hybrid protein from Neisseria meningitidis, which contains both a peroxiredoxin and a glutaredoxin domain, has been isolated. The enzyme was active in the reduction of various peroxides and dehydroascorbate in the presence of reduced glutathione. These findings suggest that both the peroxiredoxin and glutaredoxin domains are biochemically active in the fusion. Moreover, when expressed separately, the glutaredoxin domain was catalytically active and the peroxiredoxin domain possessed a weak activity when supplemented with exogenous glutaredoxin.Keywords
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