Effects of Salicylate Administration on Reputed Indices of Adrenal Cortical Activity in the Rat

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Abstract
Changes in the urinary sodium and potassium concentration and 17-ketosteroid excretion patterns of rats treated with large doses of salicylate have been compared with those seen in animals given a standard pituitary-adrenal stimulus (exposure to cold). The significance of the general lack of correlation of responses to these two forms of treatment is discussed in the light of the frequently accepted theory that salicylates stimulate the adrenal cortex