Mutation of the 9′ leucine in the GABAA receptor γ2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states
- 30 November 2001
- journal article
- Published by Elsevier in Neuropharmacology
- Vol. 41 (6) , 737-744
- https://doi.org/10.1016/s0028-3908(01)00132-0
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Structural Determinants of Fast Desensitization and Desensitization–Deactivation Coupling in GABAAReceptorsJournal of Neuroscience, 2001
- Allosteric Activation Mechanism of the α1β2γ2 γ-Aminobutyric Acid Type A Receptor Revealed by Mutation of the Conserved M2 LeucineBiophysical Journal, 1999
- GABAA receptor subunit γ2 and δ subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblastsThe Journal of Physiology, 1999
- Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptorsBritish Journal of Pharmacology, 1998
- Single channel properties of recombinant GABAA receptors containing γ2 or δ subtypes expressed with α1 and β3 subtypes in mouse L929 CellsThe Journal of Physiology, 1997
- Expression of Functional GABAA Receptors in Transfected L929 Cells Isolated by Immunomagnetic Bead SeparationNeuropharmacology, 1997
- Stoichiometry of a Recombinant GABAAReceptorJournal of Neuroscience, 1996
- Desensitized states prolong GABAA channel responses to brief agonist pulsesNeuron, 1995
- Multiphasic desensitization of the GABAA receptor in outside-out patchesBiophysical Journal, 1994
- Assembly of GABAA receptor subunits: analysis of transient single-cell expression utilizing a fluorescent substrate/marker gene techniqueJournal of Neuroscience, 1993