Apolipoprotein E ϵ4 Allele and Familial Aggregation of Alzheimer Disease
Open Access
- 1 June 1998
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 55 (6) , 810-816
- https://doi.org/10.1001/archneur.55.6.810
Abstract
APOLIPOPROTEIN E (apoE) genotype is a major risk factor for Alzheimer disease (AD). Numerous studies have reported an association between the apoE ϵ4 allele and late-1 and early-onset AD.2,3 A dose-related effect of the apoE ϵ4 allele has been suggested,4-8 but not in a limited number of series of patients who had early-onset AD or who were nonwhite.2,9-11 Results of Kaplan-Meier analyses suggested a decrease in age of onset of disease ranging from 8 to 16 years4,12,13 when the number of ϵ4 alleles increased from 0 to 2.Keywords
This publication has 3 references indexed in Scilit:
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- Apolipoprotein E element 4 association with dementia in a population-based studyNeurology, 1996
- Apo E allele frequencies in younger (age 42–50) vs older (age 65–90) womenGenetic Epidemiology, 1993