Modulation by estradiol of rabbit atrial chronotropic response to histamine

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Abstract
The chronotropic response (Δ rate) to histamine of atria from estradiol 17-β (E2; 0.1 mg/kg)-treated (14 days) rabbit was significantly greater compared to those from control rabbits. However, the maximum response of atria from rabbits treated with a higher dose of E2 (1.0 mg/kg) was not significantly different from control. Cimetidine (2.8×10−7 M) inhibited the theoretical maximum increase in rate to histamine in all 3 groups, control 25%, E2 (0.1 mg) 42% and E2 (1.0 mg) 35%.