Immunologic Induction of Malignant Lymphoma: Identification of Donor and Host Tumors in the Graft-Versus-Host Model 2

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Abstract
Primary lymphoid tumors were induced by inoculation of parental line spleen cells into H-2 incompatible F1 hybrid mice. The genotypes of lymphomas arising in 19 different parent➔F1 combinations were determined with cytotoxic antisera against H-2 specificities of donor and host. Additional chromosome marker studies established the reliability of tumor genotyping by the cytotoxicity test. According to H-2 typing, 12 primary lymphomas were of donor type, 66 of host type, and 14 of intermediate type. As a group, those parent➔F1 combinations in which donor-type lymphomas developed (group 1) showed a higher degree of histocompatibility between donor and host than those combinations in which donortype lymphomas failed to appear (group 2). Allogeneic inhibition may have suppressed the development of donortype tumors in the combinations of group 2. The development of malignant lymphomas of donor-type in the graft-versus-host reaction (GVHR) supports the concept of lymphomagenesis as a consequence of persistent stimulation by antigen.

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