Mucociliary Flow in the Trachea during Anesthesia with Enflurane, Ether, Nitrous Oxide, and Morphine

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Abstract
Tracheal mucociliary flow rates in dogs were measured with a radioactive droplet technique during thiopental anesthesia, and subsequently during enflurane, ether, and N2O-morphine anesthesia on different occasions. Enflurane, at 0.6, 1.2, 1.8 MAC [maximum acceptable concentration] produced a dose-dependent, reversible depression of mucociliary flow equal to that previously reported for halothane. N2O-halothane and N2O-morphine depressed mucociliary flow to the same extent as halothane at equivalent MAC levels. Ether did not depress mucociliary flow significantly from the thiopental control at any MAC level.