COX-2–Selective NSAIDs
- 13 September 2000
- journal article
- editorial
- Published by American Medical Association (AMA) in JAMA
- Vol. 284 (10) , 1297-1299
- https://doi.org/10.1001/jama.284.10.1297
Abstract
Gastrointestinal (GI) toxicity induced by nonsteroidal anti-inflammatory drugs (NSAIDs) is among the most common serious adverse drug events in the industrialized world. Gastroduodenal ulcers can be demonstrated by endoscopy in 10% to 20% of patients who take NSAIDs on a regular basis, and the annual incidence of clinically important GI complications approaches 2%.1 The impact of NSAIDs on public health is significant and has provided the impetus to search for safer but equally effective anti-inflammatory agents.Keywords
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