Effect of pravastatin on biliary lipid composition and bile acid synthesis in familial hypercholesterolaemia.
Open Access
- 1 March 1990
- Vol. 31 (3) , 348-350
- https://doi.org/10.1136/gut.31.3.348
Abstract
Nine patients with heterozygous familial hypercholesterolaemia were treated for eight weeks with either 40 mg pravastatin or placebo under double blind conditions. Six patients received pravastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Treatment with pravastatin resulted in a significant decrease in plasma cholesterol caused by a decrease in low density lipoprotein cholesterol (LDL-c) of 30% (p less than 0.005). We determined the effect of this medication on the lithogenicity of bile. Cholesterol saturation index of fasting gall bladder bile decreased with 23% (p less than 0.01) from 1.06 to 0.75 during treatment with pravastatin. A reduction of 24% (p less than 0.01) in molar percentage of biliary cholesterol was seen. After treatment the total bile acid excretion in faeces and the molar percentage of biliary bile acids were not significantly changed, suggesting that pravastatin does not influence bile acid biosynthesis to a significant extent. These findings indicate that treatment with pravastatin can decrease the incidence and complications of cholesterol gall stones.Keywords
This publication has 14 references indexed in Scilit:
- Simvastatin, a competitive inhibitor of HMG-CoA reductase, lowers cholesterol saturation index of gallbladder bileHepatology, 1988
- Effects of CS-514 on plasma lipids and lipoprotein composition in hypercholesterolemic subjectsAtherosclerosis, 1988
- CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal speciesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
- Effect of gemfibrozil on biliary lipid metabolism in normolipemic subjectsMetabolism, 1985
- Effect of ML-236b (compactin) on biliary excretion of bile salts and lipids, and on bile flow, in the ratBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1984
- Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance.Proceedings of the National Academy of Sciences, 1984
- Separation of plasma lipoproteins by density-gradient ultracentrifugationAnalytical Biochemistry, 1975
- Mechanisms of Lithogenic Bile Formation in American Indian Women with Cholesterol GallstonesJournal of Clinical Investigation, 1972
- Quantitative determination of the major 3-hydroxy bile acids in biological material after thin-layer chromatographic separationClinica Chimica Acta; International Journal of Clinical Chemistry, 1970
- Estimation of Serum Phospholipide and Total Phosphorus Using Chloric AcidAnalytical Chemistry, 1958