Relevance of beta receptor blockade to the negative inotropic effect induced by metabolic acidosis
- 1 May 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 7 (3) , 336-343
- https://doi.org/10.1093/cvr/7.3.336
Abstract
Acute metabolic acidosis was followed by a decrease in myocardial contractility in the heart-lung preparation. However, myocardial performance was not affected by acidosis in preparations previously treated with propranolol. It is proposed that the negative inotropic effect of metabolic acidosis was related to a decrease in response of the myocardium to circulating catecholamines and not to a direct depressing effect of acidosis upon the myocardium.Keywords
This publication has 0 references indexed in Scilit: