Studies on the Role of Ca++ and Mg++ in Complement Fixation and Immune Hemolysis
Open Access
- 1 November 1953
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 71 (5) , 374-379
- https://doi.org/10.4049/jimmunol.71.5.374
Abstract
Summary: It has been shown that Ca++ as well as Mg++ are essential for immune hemolysis. Mg++ can be replaced with a fair degree of efficiency by Co++ or Ni++. The requirement for Ca++ could not be met by Co++, Mn++, Ni++, Mg++, Cd++, Sr++, Ba++, and Zn++. Evidence is presented showing that immune hemolysis takes place in at least two reaction steps: Step 1, involving C′ fixation requires Ca++; Step 2 is a reaction of an unknown nature, which requires Mg++.Keywords
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