THE LIVER LIPIDS AND FECAL EXCRETION OF FAT AND NITROGEN IN DOGS WITH LIGATED PANCREATIC DUCTS

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Abstract
After ligation of the pancreatic ducts in 3 dogs for periods of 13 to 15 wks., the total liver lipids rose from normal values of 5.78, 4.65 and 4.46% of the wet wt. of the liver to 29.9, 16.8 and 12.8%. The changes in the lipid fractions (cholesterol, phospholipid and total fatty acids) and in their I nos. were similar to those observed in depancreatized dogs and are considered in relation to the fecal excretion of fat and protein and to the animals'' loss of wt. The results do not support the hypothesis that a fat-metabolizing hormone is produced by the pancreas.

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