Subamnesic cycloheximide treatment delays consolidation in mice.

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Abstract
Groups of C57 BL/6J mice were given passive avoidance training and then administered different doses of cycloheximide (CYC) immediately, 30 min or 1 h after training. Only the highest dose (150 mg/kg) administered immediately or 30 min after training impaired memory when the mice were tested 72 h after training. Mice were given a nonamnesic administration of CYC (30 mg/kg) or saline immediately after training and another injection of CYC (15 mg/kg, 30 mg/kg or 75 mg/kg) or saline 1 h after training. Single injections of CYC and the combination of 30 mg/kg + 15 mg/kg did not impair memory, but the combinations of 30 mg/kg + 30 mg/kg and 30 mg/kg + 75 mg/kg did impair memory. Brief CO2 anesthetization initiated immediately after training impairs memory. Mice were given either saline or 30 mg/kg CYC immediately after training and then subjected to either air or CO2 anesthetization 30 min after training. Only the group given 30 mg/kg CYC + CO2 was amnesic when tested 72 h after training. The administration of a nonamnesic dose of CYC immediately after training renders the memory susceptible to disruption by additional doses of CYC or other amnesic treatments for a longer period of time than normal. CYC apparently delays consolidation and prolongs the labile period of memory formation.

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