Selective Radioimmunoassays for Human Luteinizing Hormone (hLH) and Human Chorionic Gonadotropin (hCG)

Abstract
Antigenic relationship between human luteinizing hormone (hLH) and human chorionic gonadotropin (hCG) was first demonstrated by Ostergard in 1942. Twenty years later, Wide et al (1961) described an immunoassay for hLH based on the reactivity of hLH with an anti-hCG serum. Radioimmunoassays for hLH and hCG were introduced between 1965 and 1967 with anti-hCG and anti-hLH sera indistinctly used for both assays (Paul & Odell, 1964; Midgley & Ram, 1965; Wilde et al, 1965; Fran-chimont, 1966; Odell et al, 1966).

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