Effects of Rapid Injection of Heparinized Blood into Right and Left Ventricles in Dogs

Publisher Website
Google Scholar
Abstract
Significant changes in central and peripheral circulatory dynamics occur after rapid injections of large quantities of blood into the right and left ventricles in dogs. The injected volume probably acts as a temporary obstruction to ventricular filling with a resulting holdup of venous return in the atria and great veins. No increase in heart rate occurred during injection into either ventricle. Left ventricular stroke volume increased to "repay" the injected volume; this occurred during injection and for a period of 10 to 15 seconds after it. The response to right ventricular injection may be explained on a hydro-dynamic basis. The response to left ventricular injections was complex. Reflex effects and vasodilatation, possibly due to hemolyzed blood, may contribute to this response. A period of decreased myocardial contractility was observed after left ventricular injections.