N-(2-Mercaptoethyl)picolylamine as a Diaminomonothiolate Ligand for the “fac-[Re(CO)3]+” Core
- 8 November 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Inorganic Chemistry
- Vol. 41 (24) , 6181-6183
- https://doi.org/10.1021/ic025887+
Abstract
N-(2-Mercaptoethyl)picolylamine (MEPAH) was studied as a potentially biologically relevant ligand for the “fac-[M(CO)3]+” core (M = Re, 99Tc, 99mTc). To this end, the complex Re(CO)3(MEPA) was synthesized. The reaction of MEPAH with fac-[Re(CO)3(MeCN)3]+ took place over the course of seconds, showing the high affinity possessed by this ligand for the “fac-[Re(CO)3]+” core. A single-crystal X-ray diffraction study was performed confirming the nature of Re(CO)3(MEPA), a rare mononuclear rhenium(I) thiolate complex. Additional exploration into derivatization of the ligand backbone has afforded the analogous N-ethyl complex, Re(CO)3(MEPA-NEt). The high affinity of the ligand for the metal coupled with the ease of its derivatization implies that utilization of this ligand system for the purposes of 99mTc-radiopharmaceutical development is promising.Keywords
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