Endocytosis of Chlorambucil-Bound Anti-Tumor Globulin Following “Capping” in El4 Lymphoma Cells

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Abstract
A rabbit 7 S antibody reacting specifically with a tumor associated antigen on the surface of mouse EL4 lymphoma cells could form “caps” and subsequently undergo endocytosis even when the antibody was non-covalently bound to chlorambucil. As the alky-lation of nuclear DNA appears to be the basis of tumor inhibition by alkylating agents like chlorambucil, facilitation of the transport of chlorambucil across cell membrane by anti-tumor antibodies might explain, at least in part, the increased tumor inhibition by chlorambucil bound anti-tumor antibodies compared to tumor inhibition by equivalent amounts of tumor antibodies or chlorambucil alone.