Studies Concerning the Sensitizing Effect of Cobalt

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Abstract
The joint reactions given by cobalt salts or their traces with bichromate and nickel in the skin were studied to determine whether the positivity of the test for the cobalt salt means a true sensitization or a non-specific joint reaction. Patients [1280] suffering from occupational skin disease were routinely tested epicutaneously with 1 percent, 2 percent and 5 percent solutions of CoCl2. Of the positive epicataneous tests obtained with 2 percent C0Cl2, 29. 5 percent could be brought into correlation with contact with cobalt during work. In the other cases a non-specific joint reaction associated with the reactions produced by more potent sensitizers could be assumed. Of the 97 turpentine-sensitized, 15 showed positive reactions to Co too in the epicutaneous test. To what extent the IT [intradermal test] for CoCl2 is helpful in the demonstration of sensitization to cobalt was studied in 47 patients. On the basis of their observations the authors give the criteria of a true sensitization to cobalt.

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