Comparative Activities of Thyroxine and its Monosodium and Disodium salts
- 1 December 1952
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 81 (3) , 670-672
- https://doi.org/10.3181/00379727-81-19981
Abstract
The activities of thyroxine (free-acid) and its monosodium and disodium salts have been compared when admd. by subcut. and oral routes in rats. The method used was thiouracil method of Dempsey and Astwood. No differences were found when the 3 compounds were admd. by the same routes. All 3 compounds were more active when admd. subcut. as compared with oral ingestion. Approx. 65% of the orally admd. hormone was absorbed as judged by the activity when given subcut.Keywords
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