Iontophoretically administered drugs acting at the N‐methyl‐D‐aspartate receptor modulate burst firing in A9 dopamine neurons in the rat
- 1 February 1992
- Vol. 10 (2) , 131-140
- https://doi.org/10.1002/syn.890100208
Abstract
Extracellular single‐unit recording and iontophoresis were used to examine the effect of N‐methyl‐D‐aspartate (NMDA) and the competitive NMDA antagonist (+/−)‐4‐(3‐phosphonopropyl)‐2‐piperazine carboxylic acid (CPP) on the firing rate and firing pattern of A9 dopamine (DA) neurons in the rat. Administration of NMDA produced a dose‐dependent increase in firing rate (up to nearly 300% of baseline at the highest ejection current), which could be blocked by iontophoretic CPP. Low currents (2+ ionophore.Keywords
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