Suppressive effect of elcatonin, an eel calcitonin analogue, on excessive urinary hydroxyproline excretion in polyostotic fibrous dysplasia (McCune-Albright's syndrome).

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Abstract
A 12-yr-old Japanese girl with polyostotic fibrous dysplasia and endocrine concomitants, was treated with elcatonin, a synthetic eel calcitonin analog, 10 MRC [mouse radius calcifying] U/twice a wk given by i.m. injection. Significant decreases in 24 h urinary content of hydroxyproline and other amino acids from bone collagen were observed during the course of treatment over 5 mo. Apparently the synthetic eel calcitonin analog exhibits the therapeutic effect in patients with polyostotic fibrous dysplasia by inhibiting bone resorption.