Mutation Screening of the ALS2 Gene in Sporadic and Familial Amyotrophic Lateral Sclerosis
Open Access
- 1 December 2003
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 60 (12) , 1768-1771
- https://doi.org/10.1001/archneur.60.12.1768
Abstract
AMYOTROPHIC LATERAL sclerosis (ALS) is an adult-onset neurodegenerative disorder characterized by the death of motor neurons in the cortex, brainstem, and spinal cord, resulting in progressive paralysis and death, usually within 3 to 5 years of symptom onset.1,2 Most ALS cases are sporadic, without any family history. Approximately 15% to 20% of cases are familial, and within these lie several distinct forms of the disease.Keywords
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