THRESHOLD STUDIES AND ISOLIMINAL MAPPING OF ELECTRICALLY ELICITED AFTERDISCHARGE IN THE CAT BRAIN

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Abstract
Thresholds for the afterdischarge response were determined in areas of the brain known to be implicated in clinical epilepsy. Highly susceptible centers were found in the cortex and the hippocampus, and isoliminal regions were mapped in each area. Gradients of threshold voltage were observed in the regions around all of the susceptible centers. The susceptible centers of the cortex were found to lie at the limit of gray and white matter in the walls of the sulci. A relationship was found to exist between the susceptibility of centers responding and the presence of large nucleated cells. Histological verification of electrode placement ruled out the existence of variability in threshold for the afterdischarge response, within as well as between species.

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