Timing of Surgery in Asymptomatic Mitral Regurgitation

Abstract
The use of an evidence-based approach to the treatment of valvular heart disease has been hampered by the lack of rigorous data on predictors of the clinical outcome. The timing of surgery in patients with asymptomatic mitral regurgitation has been especially controversial for two reasons: the various causes of valve dysfunction and the lack of a precise measure of disease severity.1 Clinical outcomes and approaches to treatment depend on the cause of valve dysfunction. For example, in patients with secondary mitral regurgitation owing to dilated cardiomyopathy or ischemic disease, the prognosis depends mainly on the underlying disease and valve surgery . . .

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