Structures of Homopurine-homopyrimidine Tract in Superhelical DNA
- 1 February 1986
- journal article
- research article
- Published by Taylor & Francis in Journal of Biomolecular Structure and Dynamics
- Vol. 3 (4) , 667-669
- https://doi.org/10.1080/07391102.1986.10508454
Abstract
For homopurine-homopyrimidine tracts in superhelical DNA, we propose a structure involving Watson-Crick and Hoogsteen paired triple helixes, hairpin loops and unstructured domains. Topologically, the whole structure is equivalent to an open region. The proposed structure is consistent with available SI cleavage, pH and alkylation data and energetics under superhelical stress; this new structure is a much more probable candidate than the one proposed by us recently (V.I. Lyamichev, S.M. Mirkin & M.D. Frank-Kamenetskii, J. Biomole. Str. Dyns 3, 327-338, 1985).This publication has 4 references indexed in Scilit:
- A pH-dependent Structural Transition in the Homopurine-homopyrimidine Tract in Superhelical DNAJournal of Biomolecular Structure and Dynamics, 1985
- An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin geneNucleic Acids Research, 1985
- Human U1 RNA genes contain an unusually sensitive nuclease S1 cleavage site within the conserved 3' flanking region.Proceedings of the National Academy of Sciences, 1984
- Complexes formed by (pyrimidine)n·(purine)nDNAs on lowering the pH are three-strandedNucleic Acids Research, 1979