Sex-Linked Hereditary Thrombocytopenia as a Variant of Wiskott–Aldrich Syndrome

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Abstract
SEX-linked, hereditary thrombocytopenia is a rarely reported disorder. Only 3 cases have been described.1 2 3 More commonly reported is the Wiskott–Aldrich syndrome,4 , 5 in which sex-linked, hereditary thrombocytopenia is associated with eczema, frequent infections and early death. In the family described below, sex-linked, recessive, hereditary thrombocytopenia was found on closer inspection to be related to the Wiskott–Aldrich syndrome in some respects.Family StudiesThe propositus (IV-8) was admitted to the Children's Hospital at the age of 18 months because of iron-deficiency anemia. On physical examination he was pale, and there were scattered ecchymoses. The hemoglobin concentration was 4.7 gm per 100 ml, . . .