Abstract
Four patients with a long history of colitis, splenomegaly, hypersplenism and portal hypertension were examined with angiography, with contrast medium and isotopes, liver-spleen scintigraphy and recording of portal pressure. At angiography hyperkinetic splenic and portal blood flow was demonstrated. The increased flow caused increased portal pressure, which probably produced changes in the liver often considered as slight cirrhosis at microscopy. The scintigraphy differed from Laennec cirrhosis. The liver uptake was homogeneous and no activity in the skeleton was recorded. Splenectomy cures both the hypersplenism and portal hypertension.