Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
Open Access
- 20 January 1998
- journal article
- Published by Wiley
- Vol. 420 (1) , 25-27
- https://doi.org/10.1016/s0014-5793(97)01480-4
Abstract
The tumor suppressor p53 is degraded by the ubiquitin‐proteasome system. p53 was polyubiquitinated in the presence of E1, UbcH5 as E2 and MDM2 oncoprotein. A ubiquitin molecule bound MDM2 through sul...Keywords
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