Effects of etybenzatropine and diazepam on levodopa‐induced diphasic dyskinesias in Parkinson's disease

Publisher Website
Google Scholar
Abstract
Levodopa‐induced onset and end‐of‐dose dyskinesia are rare but disabling disorders. Although they can be attenuated by increasing and dividing the daily dose of levodopa, this does not constitute a therapeutic approach. In this pilot study, etybenzatropine, an anticholinergic drug, and diazepam, a selective benzodiazepine, were administered in addition to a single dose of levodopa in nine patients with Parkinson's disease. Both drugs tended to decrease the severity and the duration of onset and end‐of‐dose dyskinesia, and to increase the duration of action of levodopa on parkinsonian symptoms.