Non-Hodgkin's lymphoma of the head and neck: A 30-year experience at the university of Florida

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Abstract
Background Outcome in previously untreated patients with non-Hodgkin's lymphoma of the head and neck needed to be assessed. Methods A retrospective review was performed of 79 patients with stage I or II non-Hodgkin's lymphoma of the head and neck treated between 1964 and 1994 with radiotherapy (RT) or combined modality therapy (CMT) at the University of Florida. Freedom from relapse, cause-specific survival, and absolute survival were analyzed by the Kaplan-Meier method. Patterns of failure were defined, and the relationship between dose and in-field recurrence was studied. Histology was classified as low grade or intermediate/high grade. Results At 10 years, absolute survival for patients with low-grade lymphoma treated with RT was 45%; absolute survival for patients with intermediate/high-grade lymphoma was 41% for those treated with RT and 57% for those who received CMT. Twenty-seven patients had a recurrence of lymphoma after initial treatment. Twenty patients (74%) had recurrences outside the radiation treatment field; 90% of these failures were in predictable sites that would be included in comprehensive lymphatic irradiation fields (Waldeyer's ring, mantle, and whole abdomen). No clear dose response was observed. Multivariate analysis showed that patients with tumors < 5 cm in diameter had improved cause-specific survival, absolute survival, and freedom from relapse compared with patients with tumors ≥ 5 cm in diameter. Conclusions Patients with non-Hodgkin's lymphoma in the head and neck with tumors ≥ 5 cm in diameter appear to have a worse prognosis than those with smaller tumors. The patterns of failure suggest that initial treatment with comprehensive lymphatic irradiation fields could potentially eliminate the majority of treatment failures. © 1999 John Wiley & Sons, Inc. Head Neck 21: 247–254, 1999.