Bistability of Membrane Conductance in Cell Adhesion Observed in a Neuron Transistor
- 8 December 1997
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 79 (23) , 4705-4708
- https://doi.org/10.1103/physrevlett.79.4705
Abstract
We attached individual nerve cells from leech ganglia to oxidized silicon using polylysine. We studied the electrical current through the cell membrane in the region of adhesion taking advantage of field-effect transistors integrated in the substrate. We found that a minute mechanical deformation of the cell triggered a bistable reversible switching of the attached membrane between states of high and low conductance. Feasible mechanisms of the nonlinear effect are discussed.Keywords
This publication has 10 references indexed in Scilit:
- Fluorescence interference-contrast microscopy of cell adhesion on oxidized siliconApplied Physics A, 1997
- Self-Gating of Ion Channels in Cell AdhesionPhysical Review Letters, 1997
- Frequency dependent signal transfer in neuron transistorsPhysical Review E, 1997
- Fluorescence interference-contrast microscopy on oxidized silicon using a monomolecular dye layerApplied Physics A, 1996
- Interfacing neurons and silicon by electrical inductionBerichte der Bunsengesellschaft für physikalische Chemie, 1996
- Mechanosensitive ChannelsAnnual Review of Physiology, 1995
- Neuron transistor: Electrical transfer function measured by the patch-clamp techniquePhysical Review Letters, 1993
- A Neuron-Silicon Junction: A Retzius Cell of the Leech on an Insulated-Gate Field-Effect TransistorScience, 1991
- Voltage dependence of 5‐hydroxytryptamine release at a synapse between identified leech neurones in culture.The Journal of Physiology, 1986
- A quantitative description of membrane current and its application to conduction and excitation in nerveThe Journal of Physiology, 1952