Autoantibodies to pyruvate dehydrogenase complex in patients with systemic sclerosis
Open Access
- 1 July 1995
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 38 (7) , 985-989
- https://doi.org/10.1002/art.1780380715
Abstract
Objective. To determine the prevalence and clinical significance of anti‐pyruvate dehydrogenase complex (anti‐PDC) antibodies in systemic sclerosis (SSc). Methods. Serum samples from patients with limited cutaneous SSc (n = 81) or diffuse cutaneous SSc (n = 63) were examined for anti‐PDC antibodies by enzyme‐linked immunosorbent assay (ELISA) and immunoblotting. Results. IgG‐ and/or IgM‐isotype anti‐PDC antibodies were demonstrated by ELISA in 26 of 144 patients with SSc (18%). By immunoblotting, 19 patients had IgG anti‐PDC antibodies. Among these patients with IgG anti‐PDC antibodies, antibody to the E1α subunit was significantly associated with the presence of laboratory abnormalities typical of primary biliary cirrhosis (PBC). Conclusion. Antibody to the E1α subunit of PDC may be a serologic indicator for the development of PBC in patients with SSc.Keywords
This publication has 12 references indexed in Scilit:
- Antihistone antibodies in patients with localized sclerodermaArthritis & Rheumatism, 1993
- Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme.The Journal of Immunology, 1990
- The E1 α and β Subunits of the Pyruvate Dehydrogenase Complex are M2‘d’ and M2‘e’ Autoantigens in Primary Biliary CirrhosisClinical Science, 1989
- Frequency of IgG and IgM autoantibodies to four specific M2 mitochondrial autoantigens in primary biliary cirrhosisHepatology, 1989
- Reactivity of primary biliary cirrhosis sera with a human fetal liver cDNA clone of branched-chain α-keto acid dehydrogenase dihydrolipoamide acyltransferase, the 52 kD mitochondrial autoantigenHepatology, 1989
- Autoantibodies to mitochondria in systemic sclerosis. frequency and characterization using recombinant cloned autoantigenArthritis & Rheumatism, 1988
- Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis.The Journal of Immunology, 1987
- Reactivities and clinical relevance of antimitochondrial antibodies to four mitochondrial inner membrane proteins in sera of patients with primary biliary cirrhosisHepatology, 1987
- Preliminary criteria for the classification of systemic sclerosis (scleroderma)Arthritis & Rheumatism, 1980
- Rheumatic disorders in primary biliary cirrhosis.Annals of the Rheumatic Diseases, 1978