Ultrastructural and histochemical study of β‐tricalcium phosphate resorbing cells in periodontium of dogs

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Abstract
β‐TCP was implanted in surgically prepared alveolar bone defects on the mesial side of the upper canine. The dogs that we used were sacrificed after 5 weeks, fixed by perfusion, and the β‐TCP resorbing cells were examined ultrastructural‐ly and histochemically, with the following results: (1) β‐TCP was resorbed by macrophages and multinucleated giant cells. (2) Mitochondria, vacuoles and Golgi apparatus were abundant in β‐TCP‐resorbing multinucleated giant cells that possessed neither ruffled borders nor clear zones. (3) The addition of tartric acid inhibited acid phosphatase activity in the cytoplasm of the multinucleated giant cells and macrophages.