The Disulfiram (Antabuse)‐Alcohol Reaction in Male Alcoholics: Its Efficient Management by 4‐Methylpyrazole
- 1 September 1981
- journal article
- research article
- Published by Wiley in Alcohol, Clinical and Experimental Research
- Vol. 5 (4) , 528-530
- https://doi.org/10.1111/j.1530-0277.1981.tb05354.x
Abstract
4‐Methylpyrazole (4‐MP), an inhibitor of alcchol dehydrogenase, rapidly abolished the accumulation of acetaldehyde following alcohol ingestion both in volunteers pretreated with the Antabuse analog calcium carbimide and in an Antabuse‐treated alcoholic. 4‐MP also attenuated other typical symptoms, including facial flushing and tachycardia, thus suggesting its usefulness in the acute treatment of severe disulfiram‐alcohol reactions.This publication has 16 references indexed in Scilit:
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