Bioactive heterocyclic analogs of the antitumor drug, podophyllotoxin
- 1 January 1988
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 25 (1) , 89-96
- https://doi.org/10.1002/jhet.5570250113
Abstract
3,4‐Methylenedioxyphenol (sesamol) condenses with pyrrolidine and aromatic aldehydes to yield Mannich bases of type4. The Mannich bases react readily with ketonic reagents to form pyrrolidinylbenzopyran derivatives which provide a simple route to antimitotic and bioactive heterocyclic analogs of the anti‐cancer drug, podophyllotoxin.Keywords
This publication has 5 references indexed in Scilit:
- Mannich base derivatives of bioactive benzyl-1,3-benzodioxo-5-olsJournal of Heterocyclic Chemistry, 1985
- Synthesis, 470-MHz proton NMR spectra, and activity of delactonized derivatives of the anticancer drug etoposideJournal of Medicinal Chemistry, 1982
- Sterilising effects of benzyl-l,3-benzodioxoles on the tsetse fly Glossina morsitans morsitans Westwood (Diptera: Glossinidae)Bulletin of Entomological Research, 1982
- New types of insect chemosterilants. Benzylphenols and benzyl-1,3-benzodioxole derivatives as additives to housefly dietJournal of Agricultural and Food Chemistry, 1979